Dual configuration with xrandr support. If xrandr is not supported (f.e. binary nvidia) this method would not work.
1) Get list of active outputs:
$ xrandr
should looks like this:
Screen 0: minimum 320 x 200, current 5392 x 1440, maximum 8192 x 8192
DVI-I-1 connected 2560x1440+0+0 (normal left inverted right x axis y axis) 597mm x 336mm
2560x1440 60.0*+
(skip)
640x350 85.1
DVI-I-2 connected 2560x1440+2832+0 (normal left inverted right x axis y axis) 597mm x 336mm
2560x1440 60.0*+
(skip)
640x350 85.1
DVI-I-1/DVI-I-2 is output names.
Next: get list of wacom devices:
$ xsetwacom --list
Wacom Bamboo Connect Pen stylus id: 12 type: STYLUS
Wacom Bamboo Connect Pen eraser id: 13 type: ERASER
Wacom Bamboo Connect Finger touch id: 14 type: TOUCH
Wacom Bamboo Connect Finger pad id: 15 type: PAD
Next: Limit input to single monitor:
$ xsetwacom set "Wacom Bamboo Connect Pen stylus" MapToOutput DVI-I-2
Option MapToOutput works only with xrandr.
Details here: http://sourceforge.net/apps/mediawiki/linuxwacom/index.php?title=Dual_and_Multi-Monitor_Set_Up#MapToOutput